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Korean J Pediatr. 2016 Nov;59(Suppl 1):S60-S63. doi: 10.3345/kjp.2016.59.11.S60. Epub 2016 Nov 30.

A 2-month-old boy with hemolytic anemia and reticulocytopenia following intravenous immunoglobulin therapy for Kawasaki disease: a case report and literature review.

Author information

1
Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
2
Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
3
Department of Pediatrics, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
4
Department of Laboratory Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Abstract

Herein, we report a rare case of hemolytic anemia with reticulocytopenia following intravenous immunoglobulin therapy in a young infant treated for Kawasaki disease. A 2-month-old boy presented with fever lasting 3 days, conjunctival injection, strawberry tongue, erythematous edema of the hands, and macular rash, symptoms and signs suggestive of incomplete Kawasaki disease. His fever resolved 8 days after treatment with aspirin and high dose infusion of intravenous immunoglobulin. The hemoglobin and hematocrit decreased from 9.7 g/dL and 27.1% to 7.4 g/dL and 21.3%, respectively. The patient had normocytic hypochromic anemia with anisocytosis, poikilocytosis, immature neutrophils, and nucleated red blood cells. The direct antiglobulin test result was positive, and the reticulocyte count was 1.39%. The patient had an uneventful recovery. However, reticulocytopenia persisted 1 month after discharge.

KEYWORDS:

Anemia; Hemolysis; Kawasaki disease; Reticulocytes

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

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