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Mitochondrion. 2017 May;34:32-35. doi: 10.1016/j.mito.2016.12.003. Epub 2016 Dec 23.

Increased levels of cell-free mitochondrial DNA in the cerebrospinal fluid of patients with multiple sclerosis.

Author information

1
Department of Neurology, Haukeland University Hospital, Bergen, Norway; KG Jebsen Centre of MS Research, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway.
2
Department of Neurology, Haukeland University Hospital, Bergen, Norway; KG Jebsen Centre of MS Research, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Norwegian MS-Registry & Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway.
3
KG Jebsen Centre of MS Research, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Norwegian MS-Registry & Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway.
4
Department of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway.
5
Department of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway. Electronic address: laurence.bindoff@nevro.uib.no.

Abstract

Mitochondrial DNA (mtDNA) can act as damage-associated molecular pattern molecule (DAMP) and initiate an inflammatory response. We hypothesized that the concentration of mtDNA might reflect inflammatory activity in multiple sclerosis and investigated therefore levels of cell-free mitochondrial DNA in cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis. Significantly higher levels of mtDNA were found in patients compared to controls and there was an inverse correlation between disease duration and mtDNA concentration. Our study suggests that mitochondria can be involved early in multiple sclerosis, but whether this is as an initiator of the inflammatory response or part of its maintenance is unclear. Further, our study suggests that changes in mtDNA may provide a novel marker for early disease activity.

KEYWORDS:

Cerebrospinal fluid; Mitochondrial-DNA; Multiple sclerosis

PMID:
28017684
DOI:
10.1016/j.mito.2016.12.003
[Indexed for MEDLINE]

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