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Trends Immunol. 2017 Mar;38(3):206-216. doi: 10.1016/j.it.2016.11.008. Epub 2016 Dec 22.

Microbial Dysbiosis in Common Variable Immune Deficiencies: Evidence, Causes, and Consequences.

Author information

1
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
2
Department of Medical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
3
Department of Pediatric Infectious Disease, University of Edinburgh, UK; Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
4
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: h.leavis@umcutrecht.nl.

Abstract

Common variable immunodeficiency (CVID) is an immune disorder that not only causes increased susceptibility to infection, but also to inflammatory complications such as autoimmunity, lymphoid proliferation, malignancy, and granulomatous disease. Recent findings implicate the microbiome as a driver of this systemic immune dysregulation. Here, we critically review the current evidence for a role of the microbiome in the pathogenesis of CVID immune dysregulation, and describe the possible immunologic mechanisms behind causes and consequences of microbial dysbiosis in CVID. We integrate this evidence into a model describing a role for the gut microbiota in the maintenance of inflammation and immune dysregulation in CVID, and suggest research strategies to contribute to the development of new diagnostic tools and therapeutic targets.

KEYWORDS:

autoimmune disease; autoinflammation; common variable immunodeficiency; immune dysregulation; microbiome

PMID:
28017520
DOI:
10.1016/j.it.2016.11.008
[Indexed for MEDLINE]

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