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Clin J Gastroenterol. 2017 Apr;10(2):147-153. doi: 10.1007/s12328-016-0708-x. Epub 2016 Dec 24.

Follicular lymphoma-related colitis resembling ulcerative colitis.

Author information

1
Department of Internal Medicine, Asanogawa General Hospital, Kosaka-Naka 83, Kanazawa, 920-8621, Japan. zenda@asanogawa-gh.or.jp.
2
Department of Internal Medicine, Asanogawa General Hospital, Kosaka-Naka 83, Kanazawa, 920-8621, Japan.
3
Department of Hematology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
4
Department of Internal Medicine, Keijyu Kanazawa Hospital, Kanazawa, Japan.
5
Department of Radiology, Asanogawa General Hospital, Kanazawa, Japan.
6
Department of Otolaryngology, Asanogawa General Hospital, Kanazawa, Japan.
7
Department of Pathology, Asanogawa General Hospital, Kanazawa, Japan.
8
Watanabe's Consultancy for Pathological Diagnosis, Kanazawa, Japan.

Abstract

Among the various manifestations of colonic involvement in malignant lymphomas, an ulcerative colitis-like appearance is rare. Herein, we describe a case in which extranodal colonic involvement resembled ulcerative colitis in a patient with advanced follicular lymphoma. A 59-year-old Japanese man with diarrhea and body weight loss was referred to our hospital. Computed tomography (CT) revealed systemic lymphadenopathy, splenomegaly, and thickening of the sigmoid colon and rectum walls. 18F-fluorodeoxy-glucose positron emission tomography (18F-FDG-PET/CT) revealed intense tubular 18F-FDG accumulation extending from the rectum to the colon at the hepatic flexure and much weaker accumulation in the systemic lymph nodes, bone marrow, and spleen. The isotope-enriched areas had an ulcerative colitis-like appearance as shown via colonoscopy. The patient was ultimately diagnosed with follicular lymphoma (stage IV A, grade 1) based on a pathological examination of the neck lymph nodes, iliac bone marrow, and colon. After six courses of chemotherapy (R-CHOP), 18F-FDG-PET/CT confirmed complete remission of the lymphoma including the colonic lesion. This is presumably the first case of ulcerative-like colitis caused by a follicular lymphoma. As a novel approach, the lymphoma-related colitis was detected by comparing the pathology results and the 18F-FDG-PET/CT results.

KEYWORDS:

18F-FDG-PET/CT; Follicular lymphoma; Lymphoma-related colitis; Lymphomatous colitis; Ulcerative colitis

PMID:
28013449
DOI:
10.1007/s12328-016-0708-x
[Indexed for MEDLINE]

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