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Arch Womens Ment Health. 2017 Apr;20(2):283-290. doi: 10.1007/s00737-016-0697-2. Epub 2016 Dec 24.

Symptoms of anxiety and depression during pregnancy and their association with low birth weight in Chinese women: a nested case control study.

Author information

1
Wuhan Medical and Health Center for Women and Children, 100 Hongkong Road, Wuhan, Hubei, 430015, China.
2
Wuhan Environmental Monitoring Center, 422 Xinhua Road, Wuhan, Hubei, China, 430015.
3
College for Public Health and Social Justice, Saint Louis University, 3545 Lafayette Avenue, Saint Louis, MO, 63104, USA.
4
School of Public Health, Sun Yat-Sen University, 135 Xingang Xi Road, Guangzhou, 510080, China.
5
School of Public Health, Brown University, Providence, RI, 02912, USA.
6
Tongji Medical College, Huazhong University of Science and Technology, 13 Hang Kong Road, Wuhan, Hubei, 430030, China.
7
College for Public Health and Social Justice, Saint Louis University, 3545 Lafayette Avenue, Saint Louis, MO, 63104, USA. zqian2@slu.edu.
8
Wuhan Medical and Health Center for Women and Children, 100 Hongkong Road, Wuhan, Hubei, 430015, China. mchwhzb62@126.com.

Abstract

This study is a nested case control study from a population-based cohort study conducted in Wuhan, China. The aim is to estimate the association between symptoms of depression during pregnancy (DDP), anxiety during pregnancy(ADP), and depression with anxiety during pregnancy (DADP) and low birth weight (LBW) and to examine the extent to which preterm birth (PTB) moderates these associations. Logistic regression analyses were used to model associations between DDP, ADP, and DADP and LBW. Models were stratified by the presence or absence of PTB to examine moderating effects. From the cohort study, 2853 had a LBW baby (cases); 5457 pregnant women served as controls. Women with DDP or ADP only were not at higher risk of having a LBW baby, but DADP was associated with increased risk of LBW (crude OR 1.41, 95% CI 1.17-1.70; adjusted OR 1.29, 95% CI 1.07-1.57), and the significant association was particularly evident between DADP and LBW in PTB, but not in full-term births. Our data suggests that DADP is related to an increased risk of LBW and that this association is most present in PTBs.

KEYWORDS:

Anxiety during pregnancy; Depression during pregnancy; Low birth weight; Preterm birth

PMID:
28013409
DOI:
10.1007/s00737-016-0697-2
[Indexed for MEDLINE]

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