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Brain Behav Immun. 2017 Aug;64:65-70. doi: 10.1016/j.bbi.2016.12.018. Epub 2016 Dec 21.

L1 retrotransposition alters the hippocampal genomic landscape enabling memory formation.

Author information

1
División de Neurociencias, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Carretera de Utrera Km 1, 41013 Sevilla, Spain.
2
División de Neurociencias, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Carretera de Utrera Km 1, 41013 Sevilla, Spain. Electronic address: amancar@upo.es.

Abstract

Somatic LINE-1 (L1) retrotransposition is a source of genomic mosaicism and potential phenotypic diversity among neurons during brain development. In the adult brain, L1 expression can be triggered by different environmental alterations, but its functional role in this context remains unknown. Here we demonstrate a neural activation-dependent increase in the number of L1 retrotransposon insertions in the hippocampus. Using both pharmacologic and genetic approaches in mice, we demonstrate that L1 expression in the adult hippocampus enables long-term memory formation. These results provide experimental evidence that L1 retrotransposition-induced genomic mosaicism is involved in cognitive processes such as memory formation.

KEYWORDS:

Gene expression; Hippocampus; LINE1; Memory formation; Retrotransposition

PMID:
28012829
DOI:
10.1016/j.bbi.2016.12.018
[Indexed for MEDLINE]

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