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Trends Pharmacol Sci. 2017 Mar;38(3):226-256. doi: 10.1016/j.tips.2016.11.009. Epub 2016 Dec 22.

Heat Shock Proteins and Cancer.

Author information

1
Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China.
2
Department of Biomedical Sciences, West Virginia School of Osteopathic Medicine, Lewisburg, WV 24901, USA. Electronic address: tliu@osteo.wvsom.edu.
3
University of Illinois College of Medicine at Chicago, Chicago, IL 60612, USA.
4
Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address: shousongc@gmail.com.

Abstract

Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding and maturation whose expression is induced by heat shock or other stressors. The major groups are classified based on their molecular weights and include HSP27, HSP40, HSP60, HSP70, HSP90, and large HSPs. HSPs play a significant role in cellular proliferation, differentiation, and carcinogenesis. In this article we comprehensively review the roles of major HSPs in cancer biology and pharmacology. HSPs are thought to play significant roles in the molecular mechanisms leading to cancer development and metastasis. HSPs may also have potential clinical uses as biomarkers for cancer diagnosis, for assessing disease progression, or as therapeutic targets for cancer therapy.

KEYWORDS:

biomarker; cancer; carcinogenesis; heat shock protein; therapeutic target

PMID:
28012700
DOI:
10.1016/j.tips.2016.11.009
[Indexed for MEDLINE]

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