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Contemp Clin Trials. 2017 Feb;53:130-136. doi: 10.1016/j.cct.2016.12.015. Epub 2016 Dec 20.

Extended-release naltrexone for pre-release prisoners: A randomized trial of medical mobile treatment.

Author information

1
Friends Research Institute, Baltimore, MD, USA. Electronic address: mgordon@friendsresearch.org.
2
Friends Research Institute, Baltimore, MD, USA.
3
Glenwood Life Counseling Center, Baltimore, MD, USA.
4
Department of Psychology, University of Maryland, College Park, MD, USA.
5
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.

Abstract

BACKGROUND:

Extended-release naltrexone (XR-NTX), is an effective treatment for opioid use disorder but is rarely initiated in US prisons or with criminal justice populations. Mobile treatment for chronic diseases has been implemented in a variety of settings. Mobile treatment may provide an opportunity to expand outreach to parolees to surmount barriers to traditional clinic treatment.

METHODS:

Male and female prisoners (240) with pre-incarceration histories of opioid use disorder who are within one month of release from prison will be enrolled in this randomized clinical trial. Participants are randomized to one of two study arms: 1) [XR-NTX-OTx] One injection of long-acting naltrexone in prison, followed by 6 monthly injections post-release at a community opioid treatment program; or 2) [XR-NTX+ MMTx] One injection of long-acting naltrexone in prison followed by 6 monthly injections post-release at the patient's place of residence utilizing mobile medical treatment. The primary outcomes are: treatment adherence; opioid use; criminal activity; re-arrest; reincarceration; and HIV risk-behaviors.

RESULTS:

We describe the background and rationale for the study, its aims, hypotheses, and study design.

CONCLUSIONS:

The use of long-acting injectable naltrexone may be a promising form of treatment for pre-release prisoners. Finally, as many individuals in the criminal justice system drop out of treatment, this study will assess whether treatment at their place of residence will improve adherence and positively affect treatment outcomes. ClinicalTrials.gov: NCT02867124.

KEYWORDS:

Criminal justice; Long-acting naltrexone; Medical mobile treatment; Prisoners

PMID:
28011389
PMCID:
PMC5274608
DOI:
10.1016/j.cct.2016.12.015
[Indexed for MEDLINE]
Free PMC Article

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