Format

Send to

Choose Destination
Acta Anaesthesiol Scand. 1989 Jul;33(5):426-8.

Excretion of morphine in human breast milk.

Author information

1
Department of Anaesthesiology, Herlev Hospital, Denmark.

Abstract

Five lactating women who underwent surgery and were treated with morphine epidurally or IV/IM in the postoperative phase were included in the study. The morphine concentrations in plasma and breast milk were determined 0, 15, 30, 45, 60, 90, 120, 240, 360 and 480 min after drug administration by means of a specific radioimmunoassay for morphine. The milk-to-plasma ratio was 2.45 +/- 0.8 (mean +/- s.d.). The amount of morphine transferred by nursing is, even at the peak concentration of 500 ng/ml milk, small and will hardly cause respiratory depression or drowsiness in the child.

PMID:
2800981
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center