Format

Send to

Choose Destination
Am J Transplant. 2017 Jun;17(6):1563-1573. doi: 10.1111/ajt.14181. Epub 2017 Feb 2.

Reactivation of Latent HPV Infections After Renal Transplantation.

Author information

1
Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, the Netherlands.
2
Department of Nephrology, Radboud University Medical Center, Nijmegen, the Netherlands.
3
Department of Dermatology, Radboud University Medical Center, Nijmegen, the Netherlands.
4
Department of Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands.
5
Delft Diagnostic Laboratory, Rijswijk, the Netherlands.
6
Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands.

Abstract

Female renal transplant recipients (RTRs) have an increased risk for developing human papillomavirus (HPV)-related (pre)malignant lesions of the genital tract. This study aims to assess the genital prevalence of HPV before and after renal transplantation (RT). In female patients who were counseled for RT at the Radboud University Medical Center Nijmegen, the Netherlands, gynecological examination was performed at first visit, and 1 and 2 years later. HPV self-sampling and questionnaires on sexual behavior were performed every 3 months. In 65 patients who underwent RT, the high-risk human papillomavirus (hrHPV) prevalence as assessed with the highly sensitive SPF10 -LiPA25 test increased significantly from 19% before to 31% after RT (p = 0.045). Based upon the clinically validated Cobas 4800 HPV test, the hrHPV prevalence increased from 10% before to 14% after RT (p = 0.31). During follow-up, no changes in sexual behavior were reported. Thirty-three patients who did not undergo RT showed a hrHPV prevalence of 21% at study entry and of 27% after 12 months with the sensitive test, and a stable prevalence of 16% with the clinically validated test. The results of this study indicate that activation of latent HPV infections may contribute to the increased risk of HPV-related (pre)malignant lesions in female RTRs.

KEYWORDS:

cancer/malignancy/neoplasia; clinical research/practice; infection and infectious agents; kidney transplantation/nephrology; obstetrics and gynecology; preventive healthcare; viral: papillomavirus

PMID:
28009475
DOI:
10.1111/ajt.14181
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center