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Neuron. 2016 Dec 21;92(6):1154-1157. doi: 10.1016/j.neuron.2016.12.014.

Shaping Early Networks to Rule Mature Circuits: Little MiRs Go a Long Way.

Author information

1
Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK.
2
Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK. Electronic address: beatriz.rico@kcl.ac.uk.

Abstract

Normative cortical processing depends on precise interactions between excitatory and inhibitory neurons. In this issue of Neuron, Lippi et al. (2016) identify miR-101 as a master regulator coordinating molecular programs during development that ultimately impact the activity of mature networks.

KEYWORDS:

E/I balance; development; microRNAs; neural circuits

PMID:
28009269
DOI:
10.1016/j.neuron.2016.12.014
[Indexed for MEDLINE]
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