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Elife. 2016 Dec 23;5. pii: e18566. doi: 10.7554/eLife.18566.

Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit.

Author information

1
Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, United States.
2
Department of Neurosurgery, Stanford University, Stanford, United States.

Abstract

The hippocampal theta rhythm plays important roles in information processing; however, the mechanisms of its generation are not well understood. We developed a data-driven, supercomputer-based, full-scale (1:1) model of the rodent CA1 area and studied its interneurons during theta oscillations. Theta rhythm with phase-locked gamma oscillations and phase-preferential discharges of distinct interneuronal types spontaneously emerged from the isolated CA1 circuit without rhythmic inputs. Perturbation experiments identified parvalbumin-expressing interneurons and neurogliaform cells, as well as interneuronal diversity itself, as important factors in theta generation. These simulations reveal new insights into the spatiotemporal organization of the CA1 circuit during theta oscillations.

KEYWORDS:

computational; computational biology; hippocampus; inhibition; model network; mouse; neuroscience; oscillation; rat; systems biology; theta

PMID:
28009257
PMCID:
PMC5313080
DOI:
10.7554/eLife.18566
[Indexed for MEDLINE]
Free PMC Article

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