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ACS Appl Mater Interfaces. 2017 Jan 11;9(1):266-278. doi: 10.1021/acsami.6b14774. Epub 2016 Dec 23.

Lead-Free Piezoelectric (Ba,Ca)(Zr,Ti)O3 Thin Films for Biocompatible and Flexible Devices.

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National Institute for Laser, Plasma and Radiation Physics , 077125 Magurele, Romania.
CNR-ISC, Istituto dei Sistemi Complessi , Area della Ricerca di Roma-Tor Vergata, Via del Fosso del Cavaliere 100, I-00133 Rome, Italy.
Institute of Biochemistry of the Romanian Academy , 296 Splaiul Independentei, 060031 Bucharest, Romania.
Medinsys Craiova , Calea Unirii 32, 200409 Craiova, Romania.
Faculty of Mechanics, University of Craiova , Alexandru Ioan Cuza 13, 200585 Craiova, Romania.
Department of Surgery, Harvard Medical School and Massachusetts General Hospital , 55 Fruit Street White 506, Boston, Massachusetts 02114, United States.


In this work, we report the synthesis of functional biocompatible piezoelectric (1 - x)Ba(Ti0.8Zr0.2)TiO3-x(Ba0.7Ca0.3)TiO3, x = 0.45 (BCZT45), thin films with high piezoelectric properties. Pulsed-laser-based techniques, classical pulsed-laser deposition and matrix-assisted pulsed-laser evaporation, were used to synthesize the BCZT45 thin films. The second technique was employed in order to ensure growth on polymer flexible Kapton substrates. The BCZT45 thin films grown by both techniques show similar structural properties and high piezoelectric coefficient coupling between the mechanical loading and electrical potential. While it has long been shown that the electrical potential favors biological processes like osteogenesis, the assessment of cell adhesion and osteogenic differentiation onto BCZT materials has not yet been demonstrated. We prove here for the first time that BCZT 45 coatings on Kapton polymer substrates provide optimal support for osteogenic differentiation of mesenchymal stem cells in the bone marrow.


biocompatible materials; laser processing; lead-free thin films; mesenchymal stem cells; osteogenic differentiation

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