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Nat Cell Biol. 2016 Dec 23;19(1):12-14. doi: 10.1038/ncb3458.

Y chromothripsis?

Author information

1
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Seattle, Washington 98109, USA.

Abstract

Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process, including a role for non-homologous end joining.

PMID:
28008180
DOI:
10.1038/ncb3458
[Indexed for MEDLINE]

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