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Science. 2016 Dec 23;354(6319):1587-1590. doi: 10.1126/science.aah6066.

Active cortical dendrites modulate perception.

Author information

1
Institute for Biology, Neuronal Plasticity, Humboldt Universität zu Berlin, D-10117, Berlin, Germany.
2
Institute for Synaptic Physiology, University Medical Center Hamburg-Eppendorf, D-20251, Hamburg, Germany.
3
Institute for Biology, Experimental Biophysics, Humboldt Universität zu Berlin, D-10115, Berlin, Germany.
4
Institute for Biology, Neuronal Plasticity, Humboldt Universität zu Berlin, D-10117, Berlin, Germany. matthew.larkum@hu-berlin.de.

Abstract

There is as yet no consensus concerning the neural basis of perception and how it operates at a mechanistic level. We found that Ca2+ activity in the apical dendrites of a subset of layer 5 (L5) pyramidal neurons in primary somatosensory cortex (S1) in mice is correlated with the threshold for perceptual detection of whisker deflections. Manipulating the activity of apical dendrites shifted the perceptual threshold, demonstrating that an active dendritic mechanism is causally linked to perceptual detection.

PMID:
28008068
DOI:
10.1126/science.aah6066
[Indexed for MEDLINE]

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