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Science. 2016 Dec 23;354(6319):1543. doi: 10.1126/science.aaf6236.

Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".

Author information

  • 1Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
  • 2Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. steve.gamblin@crick.ac.uk.

Abstract

Jiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophilum This landmark structure has brought invaluable insights into the activation mechanism of this essential methyltransferase. However, the analysis of the x-ray data discussed below suggests that the description of oncogenic H3K27M peptide binding to the active site is incorrect.

PMID:
28008037
DOI:
10.1126/science.aaf6236
[PubMed - in process]
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