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J Cell Biol. 2017 Jan 2;216(1):13-15. doi: 10.1083/jcb.201611097. Epub 2016 Dec 22.

ARF1 at the crossroads of podosome construction and function.

Author information

1
Centre Cardiothoracique de Bordeaux, U1045, Université de Bordeaux, 33000 Bordeaux, France elisabeth.genot@inserm.fr.

Abstract

Podosomes are actin-based proteolytic microdomains of the plasma membrane found in cells that travel across tissues. In this issue, Rafiq et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605104) reveal that the small guanosine triphosphatase ARF1, a well-known orchestrator of membrane traffic at the Golgi, regulates podosome formation, maintenance, and function.

PMID:
28007918
PMCID:
PMC5223615
DOI:
10.1083/jcb.201611097
[Indexed for MEDLINE]
Free PMC Article

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