Send to

Choose Destination
J Am Heart Assoc. 2016 Dec 22;5(12). pii: e004588. doi: 10.1161/JAHA.116.004588.

Early Coronary Reperfusion Facilitates Return of Spontaneous Circulation and Improves Cardiovascular Outcomes After Ischemic Cardiac Arrest and Extracorporeal Resuscitation in Pigs.

Hutin A1,2,3,4, Lamhaut L4, Lidouren F1,2,3, Kohlhauer M1,2,3, Mongardon N1,2,3,5, Carli P4, Berdeaux A1,2,3, Ghaleh B1,2,3, Tissier R6,2,3.

Author information

Inserm, U955, Equipe 03, Créteil, France.
Université Paris Est UMR_S955, DHU A-TVB, UPEC, Créteil, France.
Ecole Nationale Vétérinaire d'Alfort, Université Paris Est, Maisons-Alfort, France.
Département d'Anesthésie Réanimation, Hôpital Universitaire Necker-Enfants Malades, SAMU de Paris, Université Paris Descartes-Paris V, Paris, France.
Service d'Anesthésie et des Réanimations Chirurgicales, Réanimation Chirurgicale Cardio-vasculaire, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France.
Inserm, U955, Equipe 03, Créteil, France



Extracorporeal cardiopulmonary resuscitation (ECPR) is widely proposed for the treatment of refractory cardiac arrest. It should be associated with coronary angiography if coronary artery disease is suspected. However, the prioritization of care remains unclear in this situation. Our goal was to determine whether coronary reperfusion should be instituted as soon as possible in such situations in a pig model.


Anesthetized pigs were instrumented and submitted to coronary artery occlusion and ventricular fibrillation. After 5 minutes of untreated cardiac arrest, conventional cardiopulmonary resuscitation (CPR) was started. Fifteen minutes later, ECPR was initiated for a total duration of 240 minutes. Animals randomly underwent either early or late coronary reperfusion at 20 or 120 minutes of ECPR, respectively. This timing was adapted to the kinetic of infarct extension in pigs. Return of spontaneous circulation was determined as organized electrocardiogram rhythm with systolic arterial pressure above 80 mm Hg. During conventional CPR, hemodynamic parameters were not different between groups. Carotid blood flow then increased by 70% after the onset of ECPR in both groups. No animal (0 of 7) elicited return of spontaneous circulation after late reperfusion versus 4 of 7 after early reperfusion (P=0.025). The hemodynamic parameters, such as carotid blood flow, were also improved in early versus late reperfusion groups (113±20 vs 43±17 mL/min after 240 minutes of ECPR, respectively; P=0.030), along with infarct size decrease (71±4% vs 84±2% of the risk zone, respectively; P=0.013).


Early reperfusion improved hemodynamic status and facilitated return of spontaneous circulation in a porcine model of ischemic cardiac arrest treated by ECPR.


ECMO ; cardiac arrest; cardiopulmonary resuscitation; myocardial infarction; reperfusion

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center