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Biochim Biophys Acta Gene Regul Mech. 2017 Feb;1860(2):233-245. doi: 10.1016/j.bbagrm.2016.12.006. Epub 2016 Dec 20.

Compositional and functional diversity of canonical PRC1 complexes in mammals.

Author information

1
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 201 S. University St., West Lafayette, IN 47907, USA.
2
Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 201 S. University St., West Lafayette, IN 47907, USA; Purdue University Center for Cancer Research, 201 S. University St., West Lafayette, IN 47907, USA. Electronic address: edykhui@purdue.edu.

Abstract

The compositional complexity of Polycomb Repressive Complex 1 (PRC1) increased dramatically during vertebrate evolution. What is considered the "canonical" PRC1 complex consists of four subunits originally identified as regulators of body segmentation in Drosophila. In mammals, each of these four canonical subunits consists of two to six paralogs that associate in a combinatorial manner to produce over a hundred possible distinct PRC1 complexes with unknown function. Genetic studies have begun to define the phenotypic roles for different PRC1 paralogs; however, relating these phenotypes to unique biochemical and transcriptional function for the different paralogs has been challenging. In this review, we attempt to address how the compositional diversity of canonical PRC1 complexes relates to unique roles for individual PRC1 paralogs in transcriptional regulation. This review focuses primarily on PRC1 complex composition, genome targeting, and biochemical function.

KEYWORDS:

Chromatin; Chromodomain; H2A119Ub; H3K27me3; Polycomb; Transcriptional repression

PMID:
28007606
DOI:
10.1016/j.bbagrm.2016.12.006
[Indexed for MEDLINE]

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