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Ageing Res Rev. 2017 Oct;39:3-14. doi: 10.1016/j.arr.2016.12.005. Epub 2016 Dec 19.

Dietary restriction and lifespan: Lessons from invertebrate models.

Author information

1
Buck Institute for Research on Aging, Novato, CA, USA.
2
Department of Pathology, University of Washington, Seattle, WA, USA.
3
Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. Electronic address: mhansen@sbpdiscovery.org.

Abstract

Dietary restriction (DR) is the most robust environmental manipulation known to increase active and healthy lifespan in many species. Despite differences in the protocols and the way DR is carried out in different organisms, conserved relationships are emerging among multiple species. Elegant studies from numerous model organisms are further defining the importance of various nutrient-signaling pathways including mTOR (mechanistic target of rapamycin), insulin/IGF-1-like signaling and sirtuins in mediating the effects of DR. We here review current advances in our understanding of the molecular mechanisms altered by DR to promote lifespan in three major invertebrate models, the budding yeast Saccharomyces cerevisiae, the nematode Caenorhabditis elegans, and the fruit fly Drosophila melanogaster.

KEYWORDS:

Autophagy; Flies; Metabolism; Mitochondrial respiration; Sirtuins; Worms; Yeast

PMID:
28007498
PMCID:
PMC5476520
[Available on 2018-10-01]
DOI:
10.1016/j.arr.2016.12.005
[Indexed for MEDLINE]

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