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Biomed Pharmacother. 2017 Feb;86:232-241. doi: 10.1016/j.biopha.2016.11.141. Epub 2016 Dec 19.

A focus on resveratrol and ocular problems, especially cataract: From chemistry to medical uses and clinical relevance.

Author information

1
Department of Zoology, University of Madras, Guindy Campus, Chennai 600025, India.
2
Department of Zoology, University of Madras, Guindy Campus, Chennai 600025, India. Electronic address: manikandanramar@yahoo.co.in.
3
Department of Biochemistry, Annai Veilakkannis College for Women, Chennai 60015, India.
4
School of Chemical Science and Biotechnology, SASTRA University, Thanjavur, India. Electronic address: thiagi200@yahoo.co.in.
5
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.
6
Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Italy.
7
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
8
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: Nabavi208@gmail.com.

Abstract

Low vision and blindness are important health problems that affect millions of people throughout the world. The most common and important pathologies are diabetic retinopathy, age-related macular degeneration, glaucoma as well as cataracts. The latter consists of an opacification of the lens of the eye which impedes the passage of light and represents one of the most important causes of vision loss. Among the risk factors for cataract development, there are life-style factors such as the use of tobacco, abuse of alcohol and unhealthy diet. In light of this, dietary components that possess anti-oxidant activity, such as polyphenols for instance, can be considered good candidates for human studies in the prevention and or treatment of such diseases. Among dietary components, the antioxidant capacity of certain polyphenols is well known, and these could be good candidates. In this review we focus our attention on the current scientific literature regarding to the effects of resveratrol on cataracts and other ocular diseases, along with its potential mechanism/s of action. A large number of preclinical studies support the involvement of resveratrol in clinical trials for the prevention and treatment of eye diseases induced by oxidative stress and inflammation, such as age-related cataract.

KEYWORDS:

Cataracts; Ocular diseases; Phytochemicals; Resveratrol

PMID:
28006748
DOI:
10.1016/j.biopha.2016.11.141
[Indexed for MEDLINE]

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