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Infection. 2017 Jun;45(3):365-368. doi: 10.1007/s15010-016-0974-z. Epub 2016 Dec 21.

Hints for control of infection in unique extrahepatic vertebral alveolar echinococcosis.

Author information

1
Service des maladies infectieuses et Tropicales, Centre Hospitalier Universitaire, Besançon, 25030, Besançon cedex, France. jffaucher@free.fr.
2
Service des maladies infectieuses et Tropicales, Centre Hospitalier Universitaire, Besançon, 25030, Besançon cedex, France.
3
Service de neurochirurgie, Centre Hospitalier Universitaire, Besançon, France.
4
Laboratoire d'anatomie et cytologie pathologique, Centre Hospitalier Universitaire, Besançon, France.
5
Service de radiologie ostéo-articulaire, Centre Hospitalier Universitaire, Besançon, France.
6
Service de médecine nucléaire, Centre Hospitalier Universitaire, Besançon, France.
7
Laboratoire de parasitologie-mycologie, Centre Hospitalier Universitaire, Besançon, France.
8
WHO Collaborating Centre for Prevention and Treatment of Human Echinococcosis, Besançon, France.
9
Laboratoire de pharmacologie clinique et toxicologie, Centre Hospitalier Universitaire, Besançon, France.
10
Service d'hépatologie, Centre Hospitalier Universitaire, Besançon, France.

Abstract

The prognosis of vertebral alveolar echinococcosis (AE) is poor. We report on the unique outcome of a patient with preexisting liver cirrhosis, in whom a diagnosis of vertebral AE was established on vertebral histopathology (D4 corporectomy in 2010 for paraplegia). Therapeutic drug monitoring of albendazole (ABZ) showed that a low dosage was appropriate. The patient recovered and ABZ withdrawal was decided in 2014, with no relapse 18 months later. In this patient, infection was purely or mainly localized in the dorsal spine, and this may have been favored by liver cirrhosis. A longer follow-up is, however, needed to confirm cure.

KEYWORDS:

Alveolar echinococcosis; Cure; Therapeutic drug monitoring; Vertebral

PMID:
28004258
DOI:
10.1007/s15010-016-0974-z
[Indexed for MEDLINE]

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