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J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1218-1225. doi: 10.1093/gerona/glw240.

Chronic Inflammation: Accelerator of Biological Aging.

Author information

1
Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
2
Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France.
3
Inserm UMR 995, Université de Lille, Lille, France.

Abstract

Biological aging is characterized by a chronic low-grade inflammation level. This chronic phenomenon has been named "inflamm-aging" and is a highly significant risk factor for morbidity and mortality in the older persons. The most common theories of inflamm-aging include redox stress, mitochondrial dysfunction, glycation, deregulation of the immune system, hormonal changes, epigenetic modifications, and dysfunction telomere attrition. Inflamm-aging plays a role in the initiation and progression of age-related diseases such as type II diabetes, Alzheimer's disease, cardiovascular disease, frailty, sarcopenia, osteoporosis, and cancer. This review will cover the identification of pathways that control age-related inflammation across multiple systems and its potential causal role in contributing to adverse health outcomes.

KEYWORDS:

aging; biology; chronic diseases; inflammation

PMID:
28003373
DOI:
10.1093/gerona/glw240
[Indexed for MEDLINE]

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