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J Cell Biol. 2017 Jan 2;216(1):25-28. doi: 10.1083/jcb.201612094. Epub 2016 Dec 21.

Interrogating cellular perception and decision making with optogenetic tools.

Author information

1
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158.
2
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158 wendell.lim@ucsf.edu.
3
Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158.
4
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158.
5
Center for Systems and Synthetic Biology, University of California, San Francisco, San Francisco, CA 94158.

Abstract

Optogenetics promises to deepen our understanding of how cells perceive and respond to complex and dynamic signals and how this perception regulates normal and abnormal function. In this study, we present our vision for how these nascent tools may transform our view of fundamental cell biological processes.

PMID:
28003330
PMCID:
PMC5223619
DOI:
10.1083/jcb.201612094
[Indexed for MEDLINE]
Free PMC Article

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