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J Biol Regul Homeost Agents. 2016 Oct-Dec;30(4 Suppl 1):165-172.

Autologous bone marrow concentrate combined with platelet-rich plasma enhance bone allograft potential to induce spinal fusion.

Author information

1
Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy.
2
Department of Transfusion Medicine and Cell Therapy, Campus Bio-Medico University of Rome, Rome, Italy.
3
Department of Molecular Medicine, “Sapienza” University, Rome, Italy.
4
Rome Transplant Network, Stem Cell Transplant Unit, “Tor Vergata” University, Rome, Italy.

Abstract

Bone marrow cells concentrate (BMCs) is a source of osteoprogenitor cells and platelet-rich plasma (PRP) is a source of growth factors. The objective of the study was to determine whether BMC and PRP could increase the potential of bone allograft to induce posterolateral-lumbar spinal fusion compared to the bone allograft alone. A prospective nonrandomized radiographic study has been conduced on 10 patients with posterolateral instrumented fusion for degenerative lumbar disease with 1-year follow-up using CT scan. A fresh frozen bone allograft alone and bone allograft with a mixture of autologous BMC and PRP blended with thrombin were apposed in the right and left posterolateral side, respectively. CT showed good right fusion masses (allograft alone) in 4 patients and poor in 6; good left masses (BMC and PRP plus allograft) in 9 patients and poor in 1. The differences detected between right-side and left-side masses show an advantage in adding BMC and PRP to the bone allograft to increase spinal fusion rate.

PMID:
28002915
[Indexed for MEDLINE]

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