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Diabetes Res Clin Pract. 2017 Jan;123:63-74. doi: 10.1016/j.diabres.2016.11.002. Epub 2016 Nov 10.

Fatigue in type 1 diabetes: A systematic review of Observational studies.

Author information

1
Østfold University College, Pb 770, 1757 Halden, Norway; Institute of Clinical Medicine, University of Oslo, Klaus Torgårds vei 3, 0372 Oslo, Norway. Electronic address: oystein.jensen@hiof.no.
2
Research and Development Department, Telemark Hospital Trust, Ulefossvegen, 3710 Skien, Norway; Institute of Clinical Medicine, University of Oslo, Klaus Torgårds vei 3, 0372 Oslo, Norway. Electronic address: tomm.bernklev@medisin.uio.no.
3
Østfold University College, Pb 770, 1757 Halden, Norway; Østfold Hospital Trust, Kalnesveien 300, 1714 Grålum, Norway. Electronic address: lars.p.jelsness-jorgensen@hiof.no.

Abstract

AIM:

To systematically review the literature on fatigue in people with type 1 diabetes.

METHODS:

In the period from April to June 2015 and with an updated search in May 2016, eight electronic databases as well as the grey literature were searched. Studies of all types of design were included if they reported data on fatigue in adult people with type 1 diabetes. All studies were assessed for quality.

RESULTS:

Out of 4259 references (including grey literature), 10 papers were reviewed in full. Three of these papers investigated fatigue as the primary endpoint, and one was assessed to be high quality. Two papers provided a definition of fatigue. Prevalence estimates ranged from 23 to 40%, dependent on the cut-off used. Six different questionnaires were used to measure fatigue/vitality and these were only validated to a limited extent in a diabetes population. Several demographic, personal and clinical factors were associated with fatigue, but the results were conflicting.

CONCLUSIONS:

Few studies have been published that investigate fatigue in type 1 diabetes and there is a large variability in findings due to different measurement methods and factors investigated. There is still an unmet need to understand what contributes to fatigue in these patients through rigorous research.

KEYWORDS:

Chronic fatigue; Fatigue; Patient reported outcome; Type 1 diabetes; Vitality

PMID:
28002753
DOI:
10.1016/j.diabres.2016.11.002
[Indexed for MEDLINE]

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