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Synapse. 2017 Jun;71(6). doi: 10.1002/syn.21955. Epub 2017 Jan 27.

VTA DA neuron excitatory synapses in Shank3 Δex4-9 mouse line.

Author information

1
Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland.

Abstract

Several mutations within SHANK3 gene have been identified in Autism Spectrum Disorder patients and several studies have now started to show that those mutations could impact different brain circuits leading to the heterogeneity of the disease. Here we show that, compared to a mouse model lacking SHANK3 proline-rich containing isoforms, in a mouse model lacking SHANK3 ANK(yrin)-domain containing isoforms, the excitatory synaptic transmission within the Ventral Tegmental Area is not affected. We discuss about the possibility that different domains of SHANK3 are involved in regulating the synapses in a circuit-specific manner resulting in different behavioral and synaptic phenotypes.

KEYWORDS:

Autism; Dopamine; SHANK3; Ventral Tegmental Area

PMID:
28002633
DOI:
10.1002/syn.21955
[Indexed for MEDLINE]

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