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Dev Dyn. 2017 Apr;246(4):208-216. doi: 10.1002/dvdy.24480. Epub 2017 Feb 6.

Ectoderm-mesoderm crosstalk in the embryonic limb: The role of fibroblast growth factor signaling.

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Department of Cell and Neurobiology, Broad CIRM Center for Regenerative Medicine & Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, California.
Departamento de Anatomía y Biología Celular, Facultad de Medicina, Universidad de Cantabria, 39011, Santander, Spain.
Instituto de Biomedicina y Biotecnología de Cantabria, CSIC-SODERCAN-Universidad de Cantabria, 39011, Santander, Spain.


In this commentary we focus on the function of FGFs during limb development and morphogenesis. Our goal is to understand, interpret and, when possible, reconcile the interesting findings and conflicting results that remain unexplained. For example, the cell death pattern observed after surgical removal of the AER versus genetic removal of the AER-Fgfs is strikingly different and the field is at an impasse with regard to an explanation. We also discuss the idea that AER function may involve signaling components in addition to the AER-FGFs and that signaling from the non-AER ectoderm may also have a significant contribution. We hope that a re-evaluation of current studies and a discussion of outstanding questions will motivate new experiments, especially considering the availability of new technologies, that will fuel further progress toward understanding the intricate ectoderm-to-mesoderm crosstalk during limb development. Developmental Dynamics 246:208-216, 2017.


AER; FGFs; limb development

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