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Ann Transl Med. 2016 Nov;4(22):446. doi: 10.21037/atm.2016.11.34.

Coincidence of thymoma and breast cancer and in a 56-year-old female patient.

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"Microdiagnostics" Ltd., Thessaloniki, Greece.
Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Surgery Department (NHS), University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
Ear, Nose and Throat Department, "St. Luke's", Private Hospital, Panorama, Thessaloniki, Greece.
Thoracic Surgery Department, "Theagenio" Cancer Hospital, Thessaloniki, Greece.
Pathology Department, "Theagenio" Cancer Hospital, Thessaloniki, Greece.
Department of Anatomy, Democritus University of Thrace, Alexandroupolis, Greece.


We present a case of a 56-year-old female, with a familial history of breast, lung and brain cancer, which revealed a breast tumor, located in the upper outer quadrant of the left breast. During the routinely staging examinations, a 15 cm intrathoracic tumor was found in the upper left mediastinum, penetrating the pericardium and a smaller tumor, in the left side of parietal pleura. Core biopsies from both lesions, revealed a lobular carcinoma of the breast classic type, grade II (e-cadherin-, ER+, PR+, Her-2-, Ki-67 10%) and a B3 thymoma (CK19+, CD5+) penetrating the pericardium and the left lung. A synchronous removal of both tumors was scheduled, including median sternotomy and left intrapericardial pneumonectomy, followed by a modified radical left mastectomy and a sentinel lymph node biopsy. The postoperative course was uneventful. This case advocates that thymoma patients appear to have a predisposition towards developing additional neoplasms, as breast carcinoma. Clinicians should be aware of the increased incidence of extrathymic cancers, occurring in thymoma patients.


Breast cancer; thymoma

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