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Ann Transl Med. 2016 Nov;4(22):446. doi: 10.21037/atm.2016.11.34.

Coincidence of thymoma and breast cancer and in a 56-year-old female patient.

Author information

1
"Microdiagnostics" Ltd., Thessaloniki, Greece.
2
Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
3
Surgery Department (NHS), University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
4
Ear, Nose and Throat Department, "St. Luke's", Private Hospital, Panorama, Thessaloniki, Greece.
5
Thoracic Surgery Department, "Theagenio" Cancer Hospital, Thessaloniki, Greece.
6
Pathology Department, "Theagenio" Cancer Hospital, Thessaloniki, Greece.
7
Department of Anatomy, Democritus University of Thrace, Alexandroupolis, Greece.

Abstract

We present a case of a 56-year-old female, with a familial history of breast, lung and brain cancer, which revealed a breast tumor, located in the upper outer quadrant of the left breast. During the routinely staging examinations, a 15 cm intrathoracic tumor was found in the upper left mediastinum, penetrating the pericardium and a smaller tumor, in the left side of parietal pleura. Core biopsies from both lesions, revealed a lobular carcinoma of the breast classic type, grade II (e-cadherin-, ER+, PR+, Her-2-, Ki-67 10%) and a B3 thymoma (CK19+, CD5+) penetrating the pericardium and the left lung. A synchronous removal of both tumors was scheduled, including median sternotomy and left intrapericardial pneumonectomy, followed by a modified radical left mastectomy and a sentinel lymph node biopsy. The postoperative course was uneventful. This case advocates that thymoma patients appear to have a predisposition towards developing additional neoplasms, as breast carcinoma. Clinicians should be aware of the increased incidence of extrathymic cancers, occurring in thymoma patients.

KEYWORDS:

Breast cancer; thymoma

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