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Nutrients. 2016 Dec 17;8(12). pii: E792. doi: 10.3390/nu8120792.

Exercise and Beta-Glucan Consumption (Saccharomyces cerevisiae) Improve the Metabolic Profile and Reduce the Atherogenic Index in Type 2 Diabetic Rats (HFD/STZ).

Author information

1
Department of Veterinary Medicine, Federal University of Lavras, Mail Box 3037, Lavras 37200-000, Brazil. ericfrancelinoandrade@gmail.com.
2
Department of Health Sciences, Federal University of Lavras, Mail Box 3037, Lavras 37200-000, Brazil. andressaveigalima@outlook.com.
3
Department of Animal Sciences, Federal University of Lavras, Mail Box 3037, Lavras 37200-000, Brazil. inunes2611@gmail.com.
4
Department of Agricultural Sciences, Federal University of Jequitinhonha and Mucuri Valleys, Rua Vereador João Narciso, 1380-Bairro Cachoeira, Unaí 3861-000, Brazil. debora.ribeiro@ufvjm.edu.br.
5
Department of Veterinary Medicine, Federal University of Lavras, Mail Box 3037, Lavras 37200-000, Brazil. pngondim@hotmail.com.
6
Department of Veterinary Medicine, Federal University of Lavras, Mail Box 3037, Lavras 37200-000, Brazil. zangeronimo@prpg.ufla.br.
7
Department of Health Sciences, Federal University of Lavras, Mail Box 3037, Lavras 37200-000, Brazil. fernando.ferrari@dsa.ufla.br.
8
Department of Health Sciences, Federal University of Lavras, Mail Box 3037, Lavras 37200-000, Brazil. lucianojosepereira@dsa.ufla.br.

Abstract

Physical activity and the ingestion of dietary fiber are non-drug alternatives commonly used as adjuvants to glycemic control in diabetic individuals. Among these fibers, we can highlight beta-glucans. However, few studies have compared isolated and synergic effects of physical exercise and beta-glucan ingestion, especially in type 2 diabetic rats. Therefore, we evaluated the effects beta-glucan (Saccharomyces cerevisiae) consumption, associated or not to exercise, on metabolic parameters of diabetic Wistar rats. The diabetes mellitus (DM) was induced by high-fat diet (HFD) associated with a low dose of streptozotocin (STZ-35 mg/kg). Trained groups were submitted to eight weeks of exercise in aquatic environment. In the last 28 days of experiment, animals received 30 mg/kg/day of beta-glucan by gavage. Isolated use of beta-glucan decreased glucose levels in fasting, Glycated hemoglobin (HbA1c), triglycerides (TAG), total cholesterol (TC), low-density lipoprotein (LDL-C), the atherogenic index of plasma. Exercise alone also decreased blood glucose levels, HbA1c, and renal lesions. An additive effect for reducing the atherogenic index of plasma and renal lesions was observed when both treatments were combined. It was concluded that both beta-glucan and exercise improved metabolic parameters in type 2 (HFD/STZ) diabetic rats.

KEYWORDS:

dietary fibers; glycemic control; metabolic profile

PMID:
27999319
PMCID:
PMC5188447
DOI:
10.3390/nu8120792
[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

The authors declare no conflict of interest.

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