Format

Send to

Choose Destination
Thorax. 2017 Mar;72(3):206-212. doi: 10.1136/thoraxjnl-2016-208375. Epub 2016 Dec 20.

Cured meat intake is associated with worsening asthma symptoms.

Author information

1
INSERM, U1168, VIMA: Aging and Chronic Diseases. Epidemiological and Public Health Approaches, Villejuif, France.
2
Univ Versailles St-Quentin-en-Yvelines, UMR-S 1168, Montigny le Bretonneux, France.
3
Univ Paris-Sud, Kremlin-Bicêtre, France.
4
Spanish National Cancer Research Centre (CNIO), Genetic & Molecular Epidemiology Group, Human Cancer Genetics Program, Madrid, Spain.
5
Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
6
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
7
CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
8
INSERM UMR1152, Physiopathologie et épidémiologie des maladies respiratoires, équipe Epidémiologie, Paris, France.
9
Clinique Universitaire de Pneumologie, Pôle Thorax et Vaisseaux, CHU Grenoble, Grenoble, France.
10
INSERM U1055, Grenoble, France.
11
Université Alpes, Grenoble, France.
12
Instituto Nacional De Salud Publica, Mexico, currently at International Agency for Research on Cancer, Lyon, France.
13
INSERM IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Inserm, Grenoble, France.
14
IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Universite Grenoble Alpes, Grenoble, France.
15
CHU de Grenoble, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.
16
Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Abstract

BACKGROUND:

Cured meat intake-a recent carcinogenic factor-may increase the risk of COPD, but its association with asthma remains unknown. Though body mass index (BMI) is a likely risk factor for asthma, its role in the diet-asthma association as a mediator has never been studied. We investigated the association between cured meat intake and worsening asthma symptoms in adults, and the role of BMI as a potential mediator.

METHODS:

Using data from the French prospective EGEA study (baseline: 2003-2007; follow-up: 2011-2013), we applied a mediation analysis in the counterfactual framework, a marginal structural model (MSM), to estimate the direct effect of baseline cured meat intake (<1, 1-3.9, ≥4 servings/week) on change in asthma symptom score (worsening or not), and the indirect effect mediated by BMI.

RESULTS:

Among the 971 participants (mean age 43 years; 49% men; 42% with asthma), 20% reported worsening asthma symptoms during the mean follow-up time of 7 years. Using the MSM, we reported a positive direct effect of cured meat intake on worsening asthma symptoms (multivariable OR=1.76, 95% CI 1.01 to 3.06 for ≥4 vs <1 serving/week). We also reported an indirect effect mediated by BMI (OR=1.07; 95% CI 1.01 to 1.14), accounting for 14% of the total effect.

CONCLUSIONS:

Higher cured meat intake was associated with worsening asthma symptoms over time, through a direct effect and to a lesser extent an effect mediated by BMI. This research extends the effect of diet on asthma in adults.

KEYWORDS:

Asthma; Asthma Epidemiology

PMID:
27999171
DOI:
10.1136/thoraxjnl-2016-208375
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for HighWire Icon for HAL archives ouvertes
Loading ...
Support Center