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J Infect. 2017 Mar;74(3):310-313. doi: 10.1016/j.jinf.2016.12.004. Epub 2016 Dec 18.

HEV infection in French HIV-infected patients.

Author information

1
Centre de Physiopathologie de Toulouse Purpan, INSERM U1043/CNRS UMR5282/Université Toulouse III Paul-Sabatier, F-31024, Toulouse, France; CHU Toulouse, Hôpital Purpan, Laboratoire de virologie, Centre National de Référence Hépatite E, Institut Fédératif de Biologie, F-31300, Toulouse, France. Electronic address: abravanel.f@chu-toulouse.fr.
2
Centre de Physiopathologie de Toulouse Purpan, INSERM U1043/CNRS UMR5282/Université Toulouse III Paul-Sabatier, F-31024, Toulouse, France; CHU Toulouse, Hôpital Purpan, Laboratoire de virologie, Centre National de Référence Hépatite E, Institut Fédératif de Biologie, F-31300, Toulouse, France.
3
CHU Toulouse, Hôpital Purpan, Service des maladies infectieuses et tropicales, F-31049, Toulouse, France.
4
CHU Toulouse, Hôpital Purpan, Service de Gastroentérologie, F-31300, Toulouse, France.
5
Centre de Physiopathologie de Toulouse Purpan, INSERM U1043/CNRS UMR5282/Université Toulouse III Paul-Sabatier, F-31024, Toulouse, France; CHU Toulouse, Hôpital Purpan, Service des maladies infectieuses et tropicales, F-31049, Toulouse, France.

Abstract

OBJECTIVES:

The reported prevalence of anti-hepatitis E virus antibodies in HIV-positive patients from industrialized countries varies greatly. It is also difficult to compare these data with the anti-IgG prevalence in the general population because age and sex are not matched in most studies. Moreover, MSM are at increased risk of viral hepatitis.

METHODS:

HEV is endemic in southwestern France. We investigated therefore 300 HIV-infected patients consecutively attending the out-patient clinic of Toulouse University Hospital. Each HIV-infected patient was matched for sex and age with 2 healthy blood donors from the same area. They were tested for anti-HEV IgM and IgG.

RESULTS:

Anti-HEV IgG was found in 116 HIV-infected patients (38.7%) and in 284 matched controls (47.3%, p = 0.027). However, anti-HEV IgG concentration tended to be lower in HIV-patients than in controls. Anti-HEV IgM prevalence was similar HIV-infected patients (3.6%) and in matched controls (3.8%, p = 0.85).

CONCLUSION:

The prevalence and concentrations of anti-HEV IgG in HIV-infected patients from Southern-France were lower than in controls, suggesting a weaker humoral response. But their prevalences of anti-HEV IgM were similar, indicating a high incidence of HEV infection. These data do not indicate that HEV is transmitted sexually.

KEYWORDS:

HEV; HIV; Humoral response; Seroprevalence; Sexual transmission

PMID:
27998748
DOI:
10.1016/j.jinf.2016.12.004
[Indexed for MEDLINE]

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