Format

Send to

Choose Destination
Eur J Med Chem. 2017 Jan 27;126:937-943. doi: 10.1016/j.ejmech.2016.12.012. Epub 2016 Dec 9.

Synthesis and antimicrobial evaluation of novel analogues of dehydroabietic acid prepared by CH-Activation.

Author information

1
Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090 Vienna, Austria.
2
Center of X-ray Structure Analysis, University of Vienna, Währinger Straße 42, 1090 Vienna, Austria.
3
Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090 Vienna, Austria. Electronic address: nuno.maulide@univie.ac.at.

Abstract

Dehydroabietic acid (DHAA) plays an important role in drug discovery. Its modification at chemically reactive positions has been exploited to a large extent over the last decades, generating a wide range of analogues. In contrast, introduction of substituents at chemically inert positions remains a sizeable challenge. Hereby we wish to report the synthesis of a first series of C-19-arylated DHAA-analogues by application of a simple CH activation protocol, as well as their antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA).

KEYWORDS:

Antimicrobial; CH-activation; Dehydroabietic acid; Directing group; MRSA

PMID:
27997880
DOI:
10.1016/j.ejmech.2016.12.012
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center