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Curr Biol. 2016 Dec 19;26(24):R1279-R1282. doi: 10.1016/j.cub.2016.10.059.

Phagocytosis: How Macrophages Tune Their Non-professional Counterparts.

Author information

1
Program in Cell Biology, Hospital for Sick Children, 686 Bay Street, Toronto, Ontario, M5G 0A4, Canada.
2
Program in Cell Biology, Hospital for Sick Children, 686 Bay Street, Toronto, Ontario, M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada; Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, 290 Victoria Street, Toronto, Ontario, M5C 1N8, Canada. Electronic address: sergio.grinstein@sickkids.ca.

Abstract

Foreign particles and apoptotic cells are engulfed by professional phagocytes (e.g. macrophages) and non-professional phagocytes (e.g. epithelial cells). These phagocyte populations exchange information to coordinate and prioritise their activities, but the nature of these messages was unknown. Recently, IGF-1 and microvesicles were identified as means of communication between macrophages and epithelia.

PMID:
27997839
DOI:
10.1016/j.cub.2016.10.059
[Indexed for MEDLINE]
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