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Curr Biol. 2016 Dec 19;26(24):R1272-R1274. doi: 10.1016/j.cub.2016.11.007.

Cell Division: Flipping the Mitotic Switches.

Author information

1
Max-Planck-Institute of Biochemistry, Martinsried, Germany. Electronic address: zachar@biochem.mpg.de.
2
Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA. Electronic address: tyson@vt.edu.

Abstract

Alternation between DNA replication in the mother cell (S phase) and equal partitioning of the replicated chromosomes to the daughter cells (M phase) during eukaryotic cell division is governed by switches that flip protein kinases on and off. New work reveals that the M-phase promoting kinase is opposed by a phosphatase that also participates in a bistable switching mechanism.

PMID:
27997836
DOI:
10.1016/j.cub.2016.11.007
[Indexed for MEDLINE]
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