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Brain Inj. 2016;30(13-14):1683-1691. Epub 2016 Oct 24.

Volumetric and morphometric MRI findings in patients with mild traumatic brain injury.

Author information

1
a Department of Physical Medicine and Rehabilitation , Oslo University Hospital , Oslo , Norway.
2
b KG Jebsen Centre for Psychosis Research/Norwegian Centre for Mental Disorder Research (NORMENT), Division of Mental Health and Addiction , Oslo University Hospital , Oslo , Norway.
3
c Department of Psychology , University of Oslo , Oslo , Norway.
4
d Department of Radiology and Nuclear Medicine , Oslo University Hospital , Oslo , Norway.
5
e Sunnaas Rehabilitation Hospital, Department of Research , Nesoddtangen , Norway.
6
f Oslo Centre for Biostatistics and Epidemiology, Research Support Services , Oslo University Hospital , Oslo , Norway.
7
g The Intervention Centre , Oslo University Hospital , Oslo , Norway.
8
h CHARM Research Centre for Habilitation and Rehabilitation Models & Services, Institute of Health and Society, University of Oslo , Oslo , Norway.

Abstract

OBJECTIVE:

This study compared cortical and sub-cortical volumes between patients with complicated (i.e. presence of intracranial abnormality on the day-of-injury CT) and uncomplicated (i.e. absence of intracranial abnormality) mild traumatic brain injury (MTBI) 4 weeks post-injury. The study hypothesized regionally decreased brain volumes and reduced cortical thickness in patients with complicated MTBIs compared with uncomplicated MTBI.

METHODS:

This study was part of a larger 2 years cohort study on MTBI. Baseline clinical and magnetic resonance imaging (MRI) data were compared for those with complicated and uncomplicated MTBI. It identified 168 patients with MTBI (90 uncomplicated and 78 complicated), aged 16-65 years. 3T MRI-system (Signa HDxt, GE Medical Systems, Milwaukee, WI) and cortical reconstruction and volumetric segmentation by FreeSurfer software have been used.

RESULTS:

No significant differences between uncomplicated and complicated MTBIs were found in neuroanatomic volumes and cortical thickness after controlling for age, gender and education. The complicated MTBI group showed larger ventricles compared with the uncomplicated group, but this effect diluted when adjusting for potential confounders.

CONCLUSION:

The study findings suggest that the classification of complicated and uncomplicated MTBI may be too broad to differentiate volumetric and morphometric effects of injury in the early post-injury phase.

KEYWORDS:

Mild brain injury; concussion; cortical thickness; intracranial injury; neuroimaging; radiology

PMID:
27996331
DOI:
10.1080/02699052.2016.1199905
[Indexed for MEDLINE]

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