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Cancer Invest. 2017 Jan 2;35(1):1-22. doi: 10.1080/07357907.2016.1247166. Epub 2016 Dec 20.

Anticancer Activity of Curcumin and Its Analogues: Preclinical and Clinical Studies.

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a Division of Hematology, Department of General Surgery, Oncology and Pathological Anatomy , University of Messina , Messina , Italy.


Curcumin has been shown to have a wide variety of therapeutic effects, ranging from anti-inflammatory, chemopreventive, anti-proliferative, and anti-metastatic. This review provides an overview of the recent research conducted to overcome the problems with the bioavailability of curcumin, and of the preclinical and clinical studies that have reported success in combinatorial strategies coupling curcumin with other treatments. Research on the signaling pathways that curcumin treatment targets shows that it potently acts on major intracellular components involved in key processes such as genomic modulations, cell invasion and cell death pathways. Curcumin is a promising molecule for the prevention and treatment of cancer.


Apoptosis; Bioavailability; Chemotherapy; Curcumin; Synergistic effect

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