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Ther Apher Dial. 2017 Feb;21(1):96-101. doi: 10.1111/1744-9987.12475. Epub 2016 Dec 20.

Online Hemodiafiltration Reduces Bisphenol A Levels.

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Nephrology Unit, Hospital Universitario de Guadalajara, Guadalajara, Spain.
Physiology Unit, Department of Systems Biology, Laboratory of Renal Physiology and Experimental Nephrology, Alcalá de Henares, Spain.
Medicine and Medicine Specialities Department, Universidad de Alcalá (UAH), Madrid, Spain.


Several uremic toxins have been identified and related to higher rates of morbidity and mortality in dialysis patients. Bisphenol A (BPA) accumulates in patients with chronic kidney disease. The aim of this study is to demonstrate the usefulness of online hemodiafiltration (OL-HDF) in reducing BPA levels. Thirty stable hemodialysis patients were selected to participate in this paired study. During three periods of 3 weeks each, patients were switched from high-flux hemodialysis (HF-HD) to OL-HDF, and back to HF-HD. BPA levels were measured in the last session of each period (pre- and post-dialysis) using ELISA and HPLC. Twenty-two patients (mean age 73 ± 14 years; 86.4% males) were included. Measurements of BPA levels by HPLC and ELISA assays showed a weak but significant correlation (r = 0.218, P = 0.012). BPA levels decreased in the OL-HDF period of hemodialysis, in contrast to the HF-HD period when they remained stable (P = 0.002). In conclusion, OL-HDF reduced BPA levels in dialysis patients.


Bisphenol A; Hemodialysis; Online hemodiafiltration; Uremic toxins

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