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Aliment Pharmacol Ther. 2017 Feb;45(4):533-541. doi: 10.1111/apt.13897. Epub 2016 Dec 19.

The effects of aminosalicylates or thiopurines on the risk of colorectal cancer in inflammatory bowel disease.

Collaborators (697)

Colombel JF, Cosnes J, Gendre JP, Lémann M, Hébuterne X, Cortot A, Bouhnik Y, Laharie D, Dupas JL, Flourié B, Lerebours E, Beaugerie L, Peyrin-Biroulet L, Allez M, Messing B, Cadiot G, Marteau P, Soulé JC, Gornet JM, Veyrac M, Duclos B, Beau P, Bourreille A, Baumer P, Carbonnel F, Heresbach D, Metman EH, Florent C, Blain A, Faucheron JL, Bonaz B, Roblin X, Potier P, Boehm C, Kurtz T, Lamouliatte H, Nion-Larmurier I, Delchier JC, Chaussade S, Weiss AM, Cézard JP, Siproudhis L, Nahon S, Sondag D, Jian R, Souquet JC, Bord P, Coffin B, D'almagne H, Delasalle P, Fournier R, Cavicchi M, Souffran MH, Vandromme L, Guedon C, Seksik P, Michiels C, Renard P, Rogier P, Gouilloud S, Rotenberg A, Savoye G, Thevenin A, Mallet L, Brazier F, Jean F, Justum AM, Latrive JP, Gerbal JL, Pierrugues R, Chardonnal G, Picon L, Reix N, D'aubigny ND, Uettwiller H, Mallet AC, Palacci A, Bensaude RJ, Bonniaud P, Empinet O, Nisard A, Rudelli A, Tubiana B, Capelle P, Dabadie A, Evard D, Julien PE, Picon-Coste M, Schneider S, Goldfain D, Bellanger J, Blondelot JP, Lamy P, Lemière S, Mockly JF, Pellat B, Gatineau-Sailliant G, Nalet B, Nancey S, Kusielewicz D, Loison P, Popot JM, Merite F, Roux JP, Afchain P, Blanquart A, Heyries L, Reville M, Viron D, Zerbib F, Claviere C, Léostic D, Pouderoux P, Moitry A, Hagège H, Hugot JP, Humeau B, Sabate JM, Lederman E, Lescut D, Luneau F, Mesnard B, Smadja L, Steinberg M, Brun M, Macaigne G, Marchal JL, Ollivier S, Ouvry D, Perche JP, Rambaud S, Benamouzig R, Cazenave JL, Coffin JC, Blazquez M, Lagneau M, Person B, Wittersheim C, Napoleon B, Cemachovic I, Iglicki F, Howaizi M, Leprince E, Leurent B, Morin T, Darsouni R, Attar A, Baron P, Breton A, Gillion JM, Guemene JM, Jouffre C, Moreau X, Claude P, Quinton A, Abitbol V, Brichard JM, Desaint B, Bouygues M, Chatrenet P, Salmeron M, Silvie J, Waldner B, Emery Y, Moraillon A, Kunkel D, Dubois P, Faure P, L'Hirondel C, Labérenne JE, Moreau P, Pereira A, Plihon G, Wolff T, Ngo Y, Boruchowicz A, Jost B, Gotlib JP, Danne O, Raoux P, Ramond-Bouhali MJ, Baetz A, Veyres B, Chapoutot C, Le Dréau G, Filippi J, Mudry J, Kalt P, Minault S, Bounin PA, Andréani T, Charneau J, Reijasse D, Bolze JL, Thaunat JL, Le Couteulx C, Maurage C, Bader R, Codjovi P, Migairou JL, Morali A, Rey P, Molard BR, Petit R, Koch S, Cassan P, Deschamps JP, Caby CM, Meurisse JJ, Prades P, Boulant J, Diacono M, Monsch JM, Dupuy JF, Bellaiche G, Guegan M, Comte JM, Cayla JM, Le Tallec F, Meurisse F, Desurmont P, Roget L, Bouyssou P, Le Gall B, Bloch F, Larvol L, Jullien M, Moreau J, Rebouissoux L, Decroix B, Dib N, Dieterling P, Lenormand F, Lagier E, Fallourd P, Charpin S, Bertrand H, Bommelaer G, Battistelli D, Delon B, Dentant L, Dorval E, Dumortier J, Gaye-Bareyt E, Gerosa Y, Guez C, Mornet M, Benfredj P, Piperaud R, Stremsdoerfer N, Verdier E, Grinholtz A, Barjonet G, See A, Arotçarena R, Baudet A, Broyer J, Charachon A, Blondon H, Mouton P, Claudez H, Labat-Labourdette J, Haëm J, Estable P, Levy P, Rosenbaum A, Balavoine Y, Blanchi A, Coutarel P, Delaperriere N, Dervichian M, Marois F, Seroka J, Michaud L, Leroy O, Meyran E, Poilroux B, Tensaouti A, Paupard T, Agard D, Beaulieu S, Benfiguig K, Capony P, Cottereau J, Desreumaux P, Dramard JM, Duché M, Mamou P, Etienney I, D'Abrigeon G, Godeberge B, Tucat G, Puech J, Roger J, Lapalus MG, Bauret P, Houcke P, Pornin B, Champigneulle B, Cuissard L, David XR, Lombard F, Granveau A, Hamon JF, Ink O, Blondel F, Namias A, Pillon D, Reignier A, Tordjman G, Christidis C, Zirabe S, Audebert M, Bion E, Bourgeaux C, Poupardin C, Deplaix P, Fratini G, Garnier T, Desseaux G, Magois H, Lochum S, Vergier JF, Texereau P, Rat C, Uzzan F, Vidal A, Vinante N, Watrin B, Wurtz-Huckert C, Barre B, Ferbus DC, Contou JF, Coupier D, David B, Gargot D, Huc D, Barraya R, Faroux R, Fourgeaud JL, Grimprel H, Auroux J, Rey JF, Arnoux JP, Lentini F, Tardy L, Mouterde O, Spyckerelle C, Vacherot B, Weissman A, Alpérine M, Le Sidaner A, Bonnet-Eymard PO, Colson JL, Pellet D, Deltombe B, Edouard A, Maechel H, Jaillet JC, Genes J, Leveque AM, Lucidarme D, Maignan P, Gehrke NM, Sanchez J, Tusseau F, Casteur A, Bottlaender J, Constantini D, Coton T, Even P, Druart F, Riot F, Gauchet JM, Hecquet G, Henry G, Hochain P, Arpurt JP, Medini A, Dartois-Hoguin M, Moindrot H, Emery P, Periac P, Prunier A, Renkes P, Tawil-Longreen C, Vincent E, Vitte RL, Loeb C, Carwana A, Barbereau D, Bohon P, Corrieri-Baizeau C, Sahy D, Derreveaux P, David D, Desbazeille F, Fontenelle P, Slama JL, Le Mercier Y, Certin M, Reig JJ, Rosa I, Helbert T, Tounian P, Turner L, Perot V, Aillet L, Pauwels A, Barré P, Nury B, Cazalbou C, Devulder F, Durget A, Dubroca J, Gaudy D, Greff M, Jacques C, Lafarge J, Kezachian G, Le Gall R, Pariente A, Pinault T, Bismuth M, Boyer-Darrigrand N, Bretagnolle P, Carpentier S, Cholet F, Theodore C, Combes R, Combet F, Delanoe C, De Montigny S, Soudan D, Fourdan O, Minier G, Languepin J, Roche J, Ginies JL, Nouel O, Petitgars P, Robin E, Hamm R, Roques JF, Roussin-Bretagne S, Sénéjoux A, Muron S, Bardoux N, Berthelemy P, Madonia P, Carles B, Reynier C, Cuillerier E, Dadamessi I, Danis J, Debenes B, Dubuc-Rey N, Lesur G, Jouet P, Lenaerts C, Garret M, Mineur A, Chabry B, Pigot F, Rossi V, Tennenbaum R, Salloum J, Slaoui MH, Mathieu S, Papapietro V, Viola S, Bezet A, Altman C, Audan A, Calabet J, Masliah C, Fayemendy L, Duruy M, Gauffeny B, Helie L, Imani K, Janin-Manificat R, Galmiche JP, Kerlirzin A, Bedenne L, Locher C, Michaudel G, Missonnier G, Rinaldi-Dovio M, Rouillon JM, Ecuer S, Patenotte A, Bronstein JA, Baty V, Bougnol M, Bourbon P, Cerbelaud P, Chavaillon A, Boiffin F, Dubern B, De Laguierce ID, Greco F, Bouhot F, Godeberge P, Grandmaison B, Gros P, Targues G, Corallo J, Boutin J, Guillan J, Barbieux JP, Lariviere IL, Le Genissel H, Leroi H, Bellaiche M, Elie-Legrand MC, Dapoigny M, Denoyel P, Pienkowski P, Pouche P, Saurfelt MM, Thorel JM, Piche T, Travers B, Tuvignon P, Zalcberg M, Boulay G, Zamora C, Samama J, Ricotie E, De Fleury P, Maille F, Mougenel JL, Gonot O, Menat JP, Kaassis M, Lang F, Abramowitz L, Ganne N, Pecriaux O, Seyrig JA, Sobhani I, Parmentier T, Van Nieuwenhuyse A, Weber FX, Glibert A, Bineau C, Canet B, Collin C, Cordet F, Parlier DD, Carre D, Peytier A, Fein F, Barouk J, Dewannieux J, Hartwig J, Jouve JL, Laplane B, Lascar G, Legrand C, Le Marchand P, Liebaert MP, Terdiman-Pire M, Abdelli N, Neveu D, De La Lande P, De Saint Louvent P, Pelatan C, Petit A, Richecoeur M, Texier F, Cazals JB, Tissot B, Mourrut C, Doubremelle M, Foltz M, Gautier-Jubé F, Martin J, Khouri E, Lons T, Carlier-Bandu M, Monnin JL, Roche H, Willemin B, Houard X, Fatisse A, Algard M, Arab K, Borel I, Lagarrigue C, Chryssostalis A, Boutroux D, Dupuychaffray JP, Khaddari S, Mion F, Puy-Montbrun T, Girardet JP, Gury B, Landau A, Le Bihan M, Nieuviarts S, Ollivry J, Le Bourgeois P, Piquet MA, Escartin MP, Systchenko R, Venezia F, Wantiez M, Lesage X, Zrihen E, Aygalenq P, Dieumegard B, Savarieau B, Bulois P, Cattan S, Diez JL, Fauchot O, Durous E, Gazut V, Guilleminet C, Bories JM, Le Floch IJ, Vove JP, Lelouch S, Lévy P, Lhopital F, Marcato N, Mozer-Bernardeau M, Nousbaum JB, Cattan P, Plane A, Raymond JM, Roseau G, Rozental G, Boustière C, Bonny C, Cordier-Collet M, Courat L, Croguennec B, Delaunay-Tardy K, Labarriere D, Geagea E, Gottrand F, Gelsi E, Thiefin G, Wohlschies E, Miguet M, Ponsot P, Suzanne J, Teste Y, Gossart AD, Baroni JL, Benchaa B, Blanc G, Maroy B, Bonjean P, Brézault C, Bridoux-Henno L, Chayette C, Auby D, Fiorucci R, Galindo G, Hubert G, Bonneau G, Marinier E, Pouteau M, Alamdari A, Delbende B, Chamouard P, D'Abravanel P, Dall'Osto H, Hervé S, Lefebvre J, Levoir D, Lillo P, Rouch M, Mathonnet M, De Lustrac M, Ramond FJ, Roupret B, Soupison A, Ait-Ouadda D, Barbaza Y, Bayart B, Bottini T, Cochet F, Goderel I, Maury O, Mbonyingo L, Pourtau V, Rasoanarivo E, Romain-Huttin L, Sallé AV, Trang J, Admane H, Drouet E.

Abstract

BACKGROUND:

Whether aminosalicylates or thiopurines reduce the risk of colorectal cancer (CRC) in inflammatory bowel (IBD) disease is controversial.

AIM:

To assess simultaneously the chemopreventive effect of aminosalicylates or thiopurines in a case-control study nested in the CESAME observational cohort that enrolled consecutive patients with IBD between May 2004 and June 2005. Patients were followed up to December 2007.

METHODS:

Study population comprised 144 case patients who developed CRC from the diagnosis of IBD (65 and 79 cases diagnosed, respectively, before and from 2004, starting year of the prospective observational period of CESAME) and 286 controls matched for gender, age, IBD subtype and year of diagnosis, and cumulative extent of colitis. Exposure to aminosalicylates or thiopurines was defined by an exposure to the treatment during the year of the diagnosis of cancer. The propensity of receiving 5-ASA and thiopurines was quantified by a composite score taking into account patient and IBD characteristics. The role of aminosalicylates or thiopurines was assessed by multivariate analysis. Propensity scores and the history of primary sclerosing cholangitis were entered into the multivariate model for adjustment.

RESULTS:

By multivariate analysis adjusted for propensity, a significant protective effect of exposure to drugs during the year of cancer was found for aminosalicylates (OR = 0.587, 95% CI: 0.367-0.937, P = 0.0257), but not for thiopurines (OR = 0.762, 95% CI: 0.432-1.343, P = 0.3468).

CONCLUSION:

In a case-control study nested in the CESAME cohort, a significant decrease in the risk of colorectal cancer in IBD was associated with exposure to aminosalicylates, not to thiopurines.

PMID:
27995656
DOI:
10.1111/apt.13897
[Indexed for MEDLINE]
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