Format

Send to

Choose Destination
Ann Biomed Eng. 2017 Jul;45(7):1718-1730. doi: 10.1007/s10439-016-1776-2. Epub 2016 Dec 19.

Uterine Tissue Engineering and the Future of Uterus Transplantation.

Author information

1
Laboratory for Transplantation and Regenerative Medicine, Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. mats.hellstrom@gu.se.
2
, Kvinnokliniken, Blå stråket 6, 413 45, Göteborg, Sweden. mats.hellstrom@gu.se.
3
Laboratory for Transplantation and Regenerative Medicine, Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
4
, Kvinnokliniken, Blå stråket 6, 413 45, Göteborg, Sweden.

Abstract

The recent successful births following live donor uterus transplantation are proof-of-concept that absolute uterine factor infertility is a treatable condition which affects several hundred thousand infertile women world-wide due to a dysfunctional uterus. This strategy also provides an alternative to gestational surrogate motherhood which is not practiced in most countries due to ethical, religious or legal reasons. The live donor surgery involved in uterus transplantation takes more than 10 h and is then followed by years of immunosuppressive medication to prevent uterine rejection. Immunosuppression is associated with significant adverse side effects, including nephrotoxicity, increased risk of serious infections, and diabetes. Thus, the development of alternative approaches to treat absolute uterine factor infertility would be desirable. This review discusses tissue engineering principles in general, but also details strategies on how to create a bioengineered uterus that could be used for transplantation, without risky donor surgery and any need for immunosuppression. We discuss scaffolds derived from decellularized organs/tissues which may be recellularized using various types of autologous somatic/stem cells, in particular for uterine tissue engineering. It further highlights the hurdles that lay ahead in developing an alternative to an allogeneic source for uterus transplantation.

KEYWORDS:

Bioengineering; Bioreactor; Decellularization; Mesenchymal stem cells; Recellularization; Reproduction; Scaffold

PMID:
27995397
PMCID:
PMC5489617
DOI:
10.1007/s10439-016-1776-2
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center