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Comput Struct Biotechnol J. 2016 Nov 27;15:68-74. eCollection 2017.

Worsening of Verbal Fluency After Deep Brain Stimulation in Parkinson's Disease: A Focused Review.

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  • 1Center of Functionally Integrative Neuroscience (CFIN), Dept. of Clinical Medicine, Aarhus University, Denmark.

Abstract

Worsening of verbal fluency after treatment with deep brain stimulation in Parkinson's disease patients is one of the most often reported cognitive adverse effect. The underlying mechanisms of this decline are not well understood. The present focused review assesses the evidence for the reliability of the often-reported decline of verbal fluency, as well as the evidence for the suggested mechanisms including disease progression, reduced medication levels, electrode positions, and stimulation effect vs. surgical effects. Finally, we highlight the need for more systematic investigations of the large degree of heterogeneity in the prevalence of verbal fluency worsening after DBS, as well as provide suggestions for future research.

KEYWORDS:

Deep brain stimulation; Parkinson's disease; Verbal fluency

PMID:
27994799
PMCID:
PMC5155048
DOI:
10.1016/j.csbj.2016.11.003

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