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J Conserv Dent. 2016 Nov-Dec;19(6):536-540.

Histological evaluation of mineral trioxide aggregate and enamel matrix derivative combination in direct pulp capping: An in vivo study.

Author information

  • 1Department of Conservative Dentistry and Endodontics, St. Joseph Dental College and Hospital, Eluru, Andhra Pradesh, India.
  • 2Department of Conservative Dentistry and Endodontics, Lenora Institute of Dental Sciences, Rajahmundry, Andhra Pradesh, India.
  • 3Department of Conservative Dentistry and Endodontics, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
  • 4Department of Oral and Maxillofacial Pathology, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
  • 5Department of Periodontics, St. Joseph Dental College and Hospital, Eluru, Andhra Pradesh, India.

Abstract

AIM:

The aim of this study is to evaluate the response of human pulp tissue to mineral trioxide aggregate (MTA), Emdogain (EMD), and combination of MTA/EMD.

MATERIALS AND METHODS:

This study was performed on sixty intact first and second premolars of human maxillary and mandibular teeth. A standard pulpal exposure was done on all the teeth and was divided into three groups of twenty teeth each and was capped with MTA, EMD, and MTA/EMD combination. The final restoration was done with resin-modified glass ionomer cement. The teeth were then extracted on the 15th or 45th day and histological evaluation done.

RESULTS:

Differences in inflammatory response and thickness of dentin bridge formation of the exposed pulp to the three different groups were statistically evaluated using Chi-square and Mann-Whitney tests and were found to be significant. No significant difference was found between MTA/EMD and MTA in terms of calcified bridge formation and pulp inflammatory response to the capping materials.

CONCLUSIONS:

MTA and MTA/EMD combination produced a better quality hard tissue response compared with the use of EMD.

KEYWORDS:

Calcific bridge; direct pulp capping; enamel matrix derivative; histological evaluation; inflammatory response; mineral trioxide aggregate

PMID:
27994315
PMCID:
PMC5146769
DOI:
10.4103/0972-0707.194031
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