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Nutr Res. 2016 Dec;36(12):1415-1422. doi: 10.1016/j.nutres.2016.11.010. Epub 2016 Nov 23.

Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles.

Author information

1
Department of Human Nutrition, Slovak University of Agriculture in Nitra, 94976 Nitra-Chrenová, Slovakia. Electronic address: marta.habanova@uniag.sk.
2
Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, Aveiro 3810-193, Portugal. Electronic address: jorgesaraiva@ua.pt.
3
Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University in Bratislava, 83232 Bratislava, Slovakia. Electronic address: miroslav.haban@gmail.com.
4
Department of Human Nutrition, Slovak University of Agriculture in Nitra, 94976 Nitra-Chrenová, Slovakia. Electronic address: Marianna.schwarzova@uniag.sk.
5
Department of Human Nutrition, Slovak University of Agriculture in Nitra, 94976 Nitra-Chrenová, Slovakia. Electronic address: peter.chlebo@hotmail.com.
6
Department of Human Nutrition, Slovak University of Agriculture in Nitra, 94976 Nitra-Chrenová, Slovakia. Electronic address: lenkapredna@gmail.com.
7
Department of Genetics and Plant Breeding, Slovak University of Agriculture in Nitra, 94976 Nitra-Chrenová, Slovakia. Electronic address: jan.gazo@uniag.sk.
8
Department of Human Nutrition, Wrocław University of Environmental and Life Sciences, 51630 Wrocław, Poland. Electronic address: joanna.wyka@up.wroc.pl.

Abstract

Cardiovascular diseases (CVDs) are the leading causes of death, and lifestyle modification, including dietary changes, is recommended to improve this condition. In this study, regular consumption of bilberries was hypothesized to have beneficial effects on CVD risk reduction, by changes in human health indicators such as decreasing low-density lipoprotein cholesterol (LDL-C) and triglycerides (TGs) and increasing high-density lipoprotein cholesterol (HDL-C). The research involved women (n=25) and men (n=11) who consumed 150 g of frozen stored bilberries 3 times a week for 6 weeks. Anthropometric parameters, blood pressure, lipid profile, glucose, liver enzymes, creatinine, albumin, magnesium, and antiradical activity were measured. Except for the body mass index of women (P=.019), no significant changes were found for anthropometric indicators. The consumption of bilberries led to a decrease in the following parameters: total cholesterol (P=.017), LDL-C (P=.0347), TG (P=.001), glucose (P=.005), albumin (P=.001), γ-glutamyltransferase (P=.046), and a positive increase in HDL-C (P=.044). In men, additionally, favorable changes were observed in total cholesterol (P=.004), glucose (P=.015), albumin (P=.028), aspartate aminotransferase (P=.012), γ-glutamyltransferase (P=.013), and HDL-C (P=.009; in this group, LDL-C increased [P=.007]). Changes in other parameters were not significant, for both women and men. Thus, the regular intake of bilberries can be important to reduce CVDs risk, by decreasing LDL-C/TG and increasing HDL-C.

KEYWORDS:

Bilberries; Biochemical parameters; Cardiovascular diseases risk; Healthy participants; Lipid profile

PMID:
27993193
DOI:
10.1016/j.nutres.2016.11.010
[Indexed for MEDLINE]

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