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Mitochondrion. 2017 May;34:1-8. doi: 10.1016/j.mito.2016.10.007. Epub 2016 Oct 28.

Mitochondrial dysfunction in a family with psychosis and chronic fatigue syndrome.

Author information

1
Centre for Omic Sciences, Centre Tecnòlogic de Nutrició i Salut, Universitat Rovira i Virgili, Reus, Catalonia, Spain.
2
Hospital Universitari Institut Pere Mata, IISPV, Universitat Rovira i Virgili, Biomedical Network Research Centre on Mental Health (CIBERSAM), Reus, Catalonia, Spain.
3
Muscle Research and Mitochondrial Function Laboratory, Cellex-IDIBAPS, Faculty of Medicine-Universitat de Barcelona, Internal Medicine Service-Hospital Clínic de Barcelona, Biomedical Network Research Centre on Rare Diseases (CIBERER), Barcelona, Catalonia, Spain.
4
Research Group on Neuromuscular and Mitochondrial Disorders, Vall d'Hebron Institut de Recerca, Biomedical Network Research Centre on Rare Diseases (CIBERER), Barcelona, Catalonia, Spain.
5
Hospital Universitari Institut Pere Mata, IISPV, Universitat Rovira i Virgili, Biomedical Network Research Centre on Mental Health (CIBERSAM), Reus, Catalonia, Spain. Electronic address: lourdes.martorell@urv.cat.

Abstract

Mitochondrial impairment is hypothesized to be involved in chronic fatigue syndrome (CFS) and schizophrenia. We performed a clinical, genetic and functional mitochondrial study in a family consisting of a female presenting schizophrenia in addition to CFS symptoms and her mother and older sister, both presenting with CFS. The three family members showed higher blood lactate levels, higher mitochondrial mass, lower mtDNA content and overall lower mitochondrial enzymatic activities and lower oxygen consumption capacities than healthy women. This family presented mtDNA depletion; however, no mutation was identified neither in the mtDNA nor in the nuclear genes related with mtDNA depletion, even though C16179A and T16519A variants should be further studied.

KEYWORDS:

Chronic fatigue syndrome; Mitochondrial DNA; Mitochondrial respiratory chain complexes; Schizophrenia; mtDNA; mtDNA depletion

PMID:
27989882
DOI:
10.1016/j.mito.2016.10.007
[Indexed for MEDLINE]

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