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J Ethnopharmacol. 2016 Dec 24;194:1069-1077. doi: 10.1016/j.jep.2016.10.073. Epub 2016 Oct 27.

Effect of Diabetea tea ™ consumption on inflammatory cytokines and metabolic biomarkers in type 2 diabetes patients.

Author information

1
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait. Electronic address: fadia@hsc.edu.kw.
2
Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait. Electronic address: eozairi@hsc.edu.kw.
3
Summative Synergy Pharmaceutical Group (SSPG) LLC, San Diego California, USA. Electronic address: ddhaines2002@yahoo.com.
4
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, Kuwait. Electronic address: novotny@hsc.edu.kw.
5
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait. Electronic address: aad@hsc.edu.kw.
6
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait. Electronic address: basel@hsc.edu.kw.
7
Faculty of Pharmacy, Department of Pharmacology, University of Debrecen, Debrecen, Hungary. Electronic address: abdel-hamid@hsc.edu.kw.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Diabetea tea™ (DT) is an anti-diabetic alternative medicine in some Asian countries. The main constituent of DT is black tea originating from Camellia sinensis that is supplemented by 12 other medicinal plants. Black tea contains a large amount of the flavonoids catechins especially epigallocatechin gallate (EGCG) which has anti-inflammatory and antioxidative capacity. This study was undertaken to evaluate the possible effects of DT intake on inflammatory cytokines, regulatory T cells (Tregs) and metabolic biomarkers in T2DM.

MATERIALS AND METHODS:

The study included 50 patients with T2DM. The patients had received 3 cups (600ml) of DT extract or placebo (PL) extract per day during a period of 12 weeks. Intracellular cytokine expression in peripheral blood mononuclear cell (PBMC) as well as the glycemic and lipid profiles were measured at baseline and after the treatment period. The active constituents of the medicinal plants included in DT were investigated by gas chromatography-mass spectrometry (GC/MS).

RESULTS:

Ingestion of DT suppressed CD4+ T cell expression of IL-1β and Il-8 (p<0.05) and up-regulated the expression of IL-10 and the Treg/IL-17 ratio (p<0.05) which was not shown in PL. A significant decrease in HbA1c and LDL was observed at the end of the study period (p<0.05) in DT. The GC/MS analyses of DT indicated the presence of lupeol, β-Amyrin and β-sitosterol. Also analyses of individual herbs showed the presence of higher levels of lupeol and β-Amyrin in Nuga Ficus bengalensis and β-sitosterol in the Attikka Ficus racemosa, indicating that the active ingredients of DT are concentrated in these two herbs.

CONCLUSION:

The present study provides evidence that DT has hypoglycemic and antihyperlipidemic properties. Interestingly, DT has anti-inflammatory effects. These properties are attributed to the flavonoids, triterpenes and phytosterol contents of the tea. We suggest that DT protects against diabetes complications in the long term.

KEYWORDS:

Berberine; Beta amyrin; Beta sitosterol; Cinnamaldehyde; Cytokines; Diabetes; Diosgenin; Hyperglycemia; Linoleic acid; Lipoproteins; Lupeol; Regulatory T cells; The following phytochemical compounds were identified as particularly relevant to the antihypoglycemic effects described in the present report: Caffeine; Vitamin E (α-, β- and γ-tocopherols)

PMID:
27989874
DOI:
10.1016/j.jep.2016.10.073
[Indexed for MEDLINE]

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