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Trends Cell Biol. 2017 Mar;27(3):189-200. doi: 10.1016/j.tcb.2016.11.001. Epub 2016 Dec 16.

Endocytosis, Metastasis and Beyond: Multiple Facets of SNX9.

Author information

1
Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: nb141@alumni.utsw.edu.
2
Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: sandra.schmid@utsouthwestern.edu.

Abstract

Sorting nexin (SNX)9 was first discovered as an endocytic accessory protein involved in clathrin-mediated endocytosis. However, recent data suggest that SNX9 is a multifunctional scaffold that coordinates membrane trafficking and remodeling with changes in actin dynamics to affect diverse cellular processes. Here, we review the accumulated knowledge on SNX9 with an emphasis on its recently identified roles in clathrin-independent endocytic pathways, cell invasion, and cell division, which have implications for SNX9 function in human disease, including cancer.

KEYWORDS:

RhoGTPase; actin; cancer; cell motility; inflammation; invadosome; mitosis

PMID:
27989654
PMCID:
PMC5318277
DOI:
10.1016/j.tcb.2016.11.001
[Indexed for MEDLINE]
Free PMC Article

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