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Dev Cell. 2017 Jan 9;40(1):9-21. doi: 10.1016/j.devcel.2016.11.010. Epub 2016 Dec 15.

Hypertranscription in Development, Stem Cells, and Regeneration.

Author information

1
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
2
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: mrsantos@ucsf.edu.

Abstract

Cells can globally upregulate their transcriptome during specific transitions, a phenomenon called hypertranscription. Evidence for hypertranscription dates back over 70 years but has gone largely ignored in the genomics era until recently. We discuss data supporting the notion that hypertranscription is a unifying theme in embryonic development, stem cell biology, regeneration, and cell competition. We review the history, methods for analysis, underlying mechanisms, and biological significance of hypertranscription.

KEYWORDS:

Chd1; Myc; cell competition; cell number normalization; development; hypertranscription; open chromatin; proliferation; regeneration; self-renewal; stem cells

PMID:
27989554
PMCID:
PMC5225143
DOI:
10.1016/j.devcel.2016.11.010
[Indexed for MEDLINE]
Free PMC Article

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