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ACS Appl Mater Interfaces. 2017 Jan 18;9(2):1219-1225. doi: 10.1021/acsami.6b10891. Epub 2017 Jan 6.

Worm-Like Superparamagnetic Nanoparticle Clusters for Enhanced Adhesion and Magnetic Resonance Relaxivity.

Author information

1
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
2
Department of Chemistry, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
3
Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
4
Department of Radiology, Mayo Clinic , Rochester, Minnesota 55905, United States.
5
Department of Bioengineering, Institute for Genomic Biology, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.

Abstract

Nanosized bioprobes that can highlight diseased tissue can be powerful diagnostic tools. However, a major unmet need is a tool with adequate adhesive properties and contrast-to-dose ratio. To this end, this study demonstrates that targeted superparamagnetic nanoprobes engineered to present a worm-like shape and hydrophilic packaging enhance both adhesion efficiency to target substrates and magnetic resonance (MR) sensitivity. These nanoprobes were prepared by the controlled self-assembly of superparamagnetic iron oxide nanoparticles (SPIONs) into worm-like superstructures using glycogen-like amphiphilic hyperbranched polyglycerols functionalized with peptides capable of binding to defective vasculature. The resulting worm-like SPION clusters presented binding affinity to the target substrate 10-fold higher than that of spherical ones and T2 molar MR relaxivity 3.5-fold higher than that of conventional, single SPIONs. The design principles discovered for these nanoprobes should be applicable to a range of other diseases where improved diagnostics are needed.

KEYWORDS:

hyperbranched polyglycerol; magnetic resonance imaging; nonspherical nanoparticle cluster; superparamagnetic iron oxide nanoparticle; targeted imaging

PMID:
27989109
DOI:
10.1021/acsami.6b10891
[Indexed for MEDLINE]

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