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Trends Endocrinol Metab. 2017 Mar;28(3):186-198. doi: 10.1016/j.tem.2016.11.008. Epub 2016 Dec 14.

Oocyte Competence in Women with Polycystic Ovary Syndrome.

Author information

1
Unit of Gynecology and Obstetrics, IRCCS - Arcispedale Santa Maria Nuova, Viale Risorgimento 80, Reggio Emilia 42123, Italy. Electronic address: stefanopalomba@tin.it.
2
Unit of Gynecology and Obstetrics, IRCCS - Arcispedale Santa Maria Nuova, Viale Risorgimento 80, Reggio Emilia 42123, Italy.
3
Unit of Gynecology and Obstetrics, IRCCS - Arcispedale Santa Maria Nuova, Viale Risorgimento 80, Reggio Emilia 42123, Italy; University of Modena and Reggio Emilia, Via Università 4, Modena 41100, Italy.

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and affects fertility and pregnancy in cases of oligoanovulation. Ovulation induction is often used to treat anovulatory patients with PCOS, but many of these women fail to conceive and resort to assisted reproductive technologies. Alterations in oocyte competence (OC) are considered potential causative factors for subfertility in women with PCOS. In this review we present and critically assess all recent clinical and experimental data regarding OC in women with PCOS. Our analysis demonstrates that the contribution of OC to reproductive potential in women with PCOS varies and largely depends on the PCOS phenotype and comorbidities associated with PCOS.

KEYWORDS:

PCOS; competence; fertility; infertility; oocyte; quality

PMID:
27988256
DOI:
10.1016/j.tem.2016.11.008
[Indexed for MEDLINE]

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