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Acta Paediatr. 2017 Mar;106(3):454-457. doi: 10.1111/apa.13708. Epub 2017 Jan 25.

Postnatal systemic inflammation and neuro-ophthalmologic dysfunctions in extremely low gestational age children.

Author information

1
Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
2
Department of Neuroscience (INM), Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
3
Department of Ophthalmology, Trondheim University Hospital, Trondheim, Norway.
4
Department of Obstetrics, Gynecology, and Reproductive Biology, Laboratory of Genital Tract Biology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
5
Neuroepidemiology Unit, Department of Neurology, Boston Children's Hospital, and Harvard Medical School, Boston, MA, USA.
6
Division of Pediatric Neurology, Department of Pediatrics, Boston University, Boston, MA, USA.
7
Division of Neonatology, Department of Pediatrics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
8
Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA.
9
Perinatal Epidemiology Unit, Hannover Medical School, Hannover, Germany.

Abstract

AIM:

Compared to infants born at term, children born very preterm are at increased risk of visual dysfunctions and neonatal systemic inflammation. Here, we explore whether these two propensities are related.

METHODS:

As part of the ELGAN study, the concentrations of 16 mediators of inflammation were measured in blood obtained on postnatal days 1, 7, 14, 21 and 28 from 1062 children born before the 28th week of gestation. Presence of visual field deficit, strabismus and/or impaired visual fixation was recorded at age two. The concentrations of each protein were divided into quartiles within gestational week categories. We calculated odds ratios with 99% confidence intervals for having each disorder comparing children with concentration in the top quartile of each protein to children whose concentration was in the lower quartiles on the corresponding day. Analyses were adjusted for gestational age and birth weight Z-score.

RESULTS:

Only one of 80 assessments (16 proteins on five different days) was significant for visual field deficit, and one for impaired fixation. No association was found between strabismus and any inflammatory mediator.

CONCLUSION:

None of the three neuro-ophthalmologic dysfunctions assessed at two years appears to be associated with systemic inflammation measured the first four postnatal weeks.

KEYWORDS:

Inflammation; Prematurity; Strabismus; Visual development; Visual impairment

PMID:
27987368
PMCID:
PMC5303161
DOI:
10.1111/apa.13708
[Indexed for MEDLINE]
Free PMC Article

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